Interventions for managing medication-related osteonecrosis of the jaw
Interventions for managing medication-related osteonecrosis of the jaw
Cochrane Review
13 SoF Entries
Summary of Findings
Key results and quality assessments using GRADE methodology
| Outcome | Effect | Participants | Studies | Certainty |
|---|---|---|---|---|
|
Taste acuity improvement (patient-reported outcome) assessed with VAS/questionnaire where improvement in dysgeusia is defined as more than 5% improvement in the VAS scores for a mean follow-up period of 3 months
placebo |
1.4 | - | - | Not assessed |
|
Taste acuity improvement (objective outcome - continuous data) assessed with filter paper strip and filter paper disk methods for a mean follow-up period of 3 months
placebo |
0.44 | - | - | Not assessed |
|
Taste acuity improvement (objective outcome - dichotomous data) assessed with filter paper disk and Henkin's 3-drop stimulus method for a mean follow-up period of 3 months
placebo |
1.42 | - | - | Not assessed |
|
Cross-over trial - taste detection assessed with Henkin's method for a follow-up period of 6 months
placebo |
2.5 | - | - | Not assessed |
|
Cross-over trial - taste recognition assessed with Henkin's method for a follow-up period of 6 months
placebo |
3.0 | - | - | Not assessed |
|
Adverse events - follow-up range 12 weeks to 18 weeks
placebo |
5.2 | - | - | Not assessed |
|
Taste discrimination assessed with 32 taste strips with a follow-up of 8 weeks
sham control |
2.8 | - | - | Not assessed |
|
Taste acuity improvement - Patient reported outcome
placebo |
1.45 | - | - | Not assessed |
|
Taste acuity improvement - Objective outcome - Continuous - Overall taste improvement
placebo |
0.44 | - | - | Not assessed |
|
Taste acuity improvement - Objective outcome - Continuous - Taste recognition
placebo |
1.26 | - | - | Not assessed |
|
Taste acuity improvement - Objective outcome - Dichotomous - Idiopathic and zinc deficient taste disorders
placebo |
1.7 | - | - | Not assessed |
|
Adverse events
placebo |
6.21 | - | - | Not assessed |
|
Taste discrimination
sham control |
2.8 | - | - | Not assessed |
GRADE Certainty of Evidence:
High
Very confident in the effect estimate
Moderate
Moderately confident in the effect estimate
Low
Limited confidence in the effect estimate
Very Low
Very little confidence in the effect estimate
Review Information
| Review ID: | CD010470 |
| Outcomes: | 13 assessed |
Related Content
Evidence Quality Distribution:
Not assessed:
13